Interleukin-4

Interleukin-4
Struktur yang tersedia PDB Pencarian ortolog: PDBe RCSB Daftar kode ID PDB 1BBN, 1BCN, 1CYL, 1HIJ, 1HIK, 1HZI, 1IAR, 1ITI, 1ITL, 1ITM, 1RCB, 2B8U, 2B8X, 2B8Y, 2B8Z, 2B90, 2B91, 2CYK, 2D48, 2INT, 3BPL, 3BPN, 3QB7, 4YDY, 5FHX
Pengidentifikasi
Alias	IL4, Interleukin 4, IGG1 induction factor, B-cell IgG differentiation factor, B-cell stimulatory factor 1, B-cell growth factor 1, Il4, lymphocyte stimulatory factor 1
ID Eksternal	MGI: 96556; HomoloGene: 491; GeneCards: IL4; OMA:IL4 - orthologs
Lokasi gen (Manusia) Kr. Kromosom 5 (manusia) Pita 5q31.1 Awal 132,009,678 pb Akhir 132,018,370 pb
Pola ekspresi RNA Bgee Manusia Tikus (ortologi) Ekspresi tertinggi di oosit secondary oocyte Testis Gonad right uterine tube Monosit Adenohipofisis right coronary artery olfactory zone of nasal mucosa bone marrow cell Ekspresi tertinggi di neural layer of retina superior frontal gyrus spermatocyte primary visual cortex Lensa mata embrio embrio dentate gyrus of hippocampal formation granule cell ventricular zone morula Referensi data ekspresi selengkapnya BioGPS n/a
Ontologi gen Fungsi molekuler interleukin-4 receptor binding Ikatan protein plasma growth factor activity cytokine receptor binding cytokine activity Komponen seluler extracellular region extracellular space Proses biologis positive regulation of T cell differentiation dendritic cell differentiation negative regulation of endothelial cell apoptotic process negative regulation of complement-dependent cytotoxicity regulation of phosphorylation negative regulation of apoptotic process myeloid dendritic cell differentiation type 2 immune response B cell activation positive regulation of interleukin-13 production respons imun B cell differentiation T-helper 2 cell cytokine production regulation of isotype switching negative regulation of transcription, DNA-templated negative regulation of epithelial cell migration regulation of signaling receptor activity cholesterol metabolic process positive regulation of B cell proliferation positive regulation of T cell proliferation T cell activation positive regulation of MHC class II biosynthetic process negative regulation of osteoclast differentiation positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of isotype switching to IgE isotypes positive regulation of isotype switching to IgG isotypes regulation of immune response cytokine-mediated signaling pathway positive regulation of gene expression positive regulation of macroautophagy positive regulation of tyrosine phosphorylation of STAT protein activation of Janus kinase activity positive regulation of receptor-mediated endocytosis positive regulation of cold-induced thermogenesis negative regulation of neuroinflammatory response positive regulation of amyloid-beta clearance neuroinflammatory response positive regulation of cellular respiration positive regulation of ATP biosynthetic process Sumber:Amigo / QuickGO
Ortologi Spesies Manusia Tikus Entrez 3565 16189 Ensembl ENSG00000113520 ENSMUSG00000000869 UniProt P05112 P07750 RefSeq (mRNA) NM_000589.4 NM_021283 RefSeq (protein) NP_000580 NP_758858 NP_001341919 NP_067258 Location (UCSC) Chr 5: 132.01 – 132.02 Mb n/a PubMed search [1] [2]
Wikidata
Lihat/Sunting Manusia Lihat/Sunting Tikus

Interleukin-4, IL-4 (bahasa Inggris:BSF1, BCGF1, BCGF-1, MGC79402) adalah sitokina pleiotropik yang disekresi oleh sel T yang telah teraktivasi^[3] menjadi sel T_H2, bersama-sama dengan IL-5 dan IL-13.^[4] IL-4 berperan dominan dalam sistem kekebalan dan merupakan faktor yang penting dalam perkembangan hipersensitivitas,^[5] dengan fungsi seluler yang banyak tumpang-tindih dengan IL-13.^[3]

Rujukan

Basis data pengawasan otoritas: Nasional	Amerika Serikat

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