CXCL10

CXCL10
Struktur yang tersedia PDB Pencarian ortolog: PDBe RCSB Daftar kode ID PDB 1O80, 1LV9, 1O7Y, 1O7Z
Pengidentifikasi
Alias	CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1, C-X-C motif chemokine ligand 10, C-X-C motif chemokine 10
ID Eksternal	OMIM: 147310; MGI: 1352450; HomoloGene: 1203; GeneCards: CXCL10; OMA:CXCL10 - orthologs
Lokasi gen (Manusia) Kr. Kromosom 4 (manusia)[1] Pita 4q21.1 Awal 76,021,118 pb[1] Akhir 76,023,497 pb[1]
Pola ekspresi RNA Bgee Manusia Tikus (ortologi) Ekspresi tertinggi di Umbai cacing Testis Desidua nodus limfa rektum Monosit Granulosit olfactory zone of nasal mucosa otot polos epithelium of nasopharynx Ekspresi tertinggi di mesenteric lymph nodes timus limpa spermatocyte Saraf optik embrio right kidney subcutaneous adipose tissue embrio Granulosit Referensi data ekspresi selengkapnya BioGPS Data ekspresi referensi lebih lanjut
Ontologi gen Fungsi molekuler cytokine activity heparin binding CXCR3 chemokine receptor binding chemokine activity Ikatan protein plasma cAMP-dependent protein kinase regulator activity signaling receptor binding chemoattractant activity Komponen seluler extracellular region external side of plasma membrane extracellular space intracellular anatomical structure Proses biologis regulation of endothelial tube morphogenesis negative regulation of myoblast differentiation cellular response to heat respons terhadap vitamin D positive regulation of cell migration T cell chemotaxis chemokine-mediated signaling pathway cell-cell signaling response to virus muscle organ development positive regulation of monocyte chemotaxis positive regulation of release of sequestered calcium ion into cytosol endothelial cell activation positive regulation of cAMP-mediated signaling regulation of T cell chemotaxis blood circulation chemotaxis positive regulation of leukocyte chemotaxis cell surface receptor signaling pathway response to lipopolysaccharide negative regulation of myoblast fusion defense response to virus regulation of cell population proliferation respons imun positive regulation of cell population proliferation response to auditory stimulus negative regulation of angiogenesis response to cold cellular response to lipopolysaccharide response to gamma radiation positive regulation of T cell migration signal transduction positive regulation of transcription by RNA polymerase II regulation of protein kinase activity defense response inflammatory response antimicrobial humoral immune response mediated by antimicrobial peptide regulation of signaling receptor activity G protein-coupled receptor signaling pathway cytokine-mediated signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway response to bacterium neutrophil chemotaxis leukocyte chemotaxis positive chemotaxis regulation of apoptotic process Sumber:Amigo / QuickGO
Ortologi Spesies Manusia Tikus Entrez 3627 15945 Ensembl ENSG00000169245 ENSMUSG00000034855 UniProt P02778 P17515 RefSeq (mRNA) NM_001565 NM_021274 RefSeq (protein) NP_001556 NP_067249 Location (UCSC) Chr 4: 76.02 – 76.02 Mb n/a PubMed search [2] [3]
Wikidata
Lihat/Sunting Manusia Lihat/Sunting Tikus

CXCL10 (bahasa Inggris:interferon-gamma induced protein, γ-IP10, IP-10) adalah kemokina bermotif C-X-C dengan ligan 10, dan mempunyai massa 10 kDa.^[4]

IP-10 disekresi oleh beberapa sel sebagai respon terhadap hormon IFN-γ, termasuk monosit, sel endotelial, dan fibroblas.^[5]

IP-10 diketahui turut berperan sebagai:

• mediator kemotaksis bagi monosit, makrofaga, sel T, sel NK dan DC
• stimulan adhesi sel T ke sel endotelial
• aktivitas anti-tumor
• inhibitor pembentukan koloni pada sumsum tulang dan proses angiogenesis,^[6][7] setelah mengikatkan dirinya pada permukaan sel pada pencerap kemokina CXCR3.^[8]

Gen IP-10 terletak pada kromosom 4 pada kluster yang bersamaan dengan beberapa kemokina CXC lainnya.^[9]

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