CCL5

CCL5
Struktur yang tersedia PDB Pencarian ortolog: PDBe RCSB Daftar kode ID PDB 1B3A, 1EQT, 1HRJ, 1RTN, 1RTO, 1U4L, 1U4M, 1U4P, 1U4R, 2L9H, 2VXW, 5CMD, 5DNF, 5COY
Pengidentifikasi
Alias	CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP, C-C motif chemokine ligand 5
ID Eksternal	OMIM: 187011; MGI: 98262; HomoloGene: 2244; GeneCards: CCL5; OMA:CCL5 - orthologs
Lokasi gen (Manusia) Kr. Kromosom 17 (manusia)[1] Pita 17q12 Awal 35,871,491 pb[1] Akhir 35,880,793 pb[1]
Pola ekspresi RNA Bgee Manusia Tikus (ortologi) Ekspresi tertinggi di Granulosit Monosit darah nodus limfa limpa kantung empedu Usus dua belas jari epithelium of colon Umbai cacing Sumsum tulang Ekspresi tertinggi di mesenteric lymph nodes limpa superior surface of tongue timus darah Usus kosong Usus dua belas jari subcutaneous adipose tissue Paneth cell right lung Referensi data ekspresi selengkapnya BioGPS Data ekspresi referensi lebih lanjut
Ontologi gen Fungsi molekuler CCR5 chemokine receptor binding receptor signaling protein tyrosine kinase activator activity chemokine activity protein self-association CCR4 chemokine receptor binding phosphatidylinositol phospholipase C activity protein kinase activity cytokine activity CCR1 chemokine receptor binding phospholipase activator activity chemokine receptor binding homodimerisasi protein chemokine receptor antagonist activity Ikatan protein plasma chemoattractant activity pengikatan protein identik CCR chemokine receptor binding Komponen seluler sitoplasma extracellular region extracellular space Proses biologis leukocyte cell-cell adhesion positive regulation of cell-cell adhesion mediated by integrin regulation of T cell activation positive regulation of smooth muscle cell migration activation of phospholipase D activity negative regulation of viral genome replication positive regulation of ERK1 and ERK2 cascade positive regulation of innate immune response cellular response to interferon-gamma positive regulation of macrophage chemotaxis calcium ion transport Eksositosis positive regulation of calcium ion transport response to cytokine regulation of insulin secretion chemokine-mediated signaling pathway positive regulation of cellular biosynthetic process response to virus positive regulation of monocyte chemotaxis cellular response to fibroblast growth factor stimulus neutrophil chemotaxis response to tumor necrosis factor negative regulation of T cell apoptotic process positive regulation of GTPase activity negative regulation of macrophage apoptotic process positive regulation of T cell proliferation positive regulation of phosphorylation inflammatory response positive regulation of translational initiation response to toxic substance positive regulation of epithelial cell proliferation positive regulation of tyrosine phosphorylation of STAT protein cellular response to organic cyclic compound cellular calcium ion homeostasis protein tetramerization chemotaxis positive regulation of homotypic cell-cell adhesion cellular response to interleukin-1 respons imun positive regulation of viral genome replication positive regulation of receptor signaling pathway via JAK-STAT lipopolysaccharide-mediated signaling pathway positive regulation of T cell migration regulation of chronic inflammatory response positive regulation of smooth muscle cell proliferation neutrophil activation protein kinase B signaling positive regulation of cell migration positive regulation of natural killer cell chemotaxis cell-cell signaling eosinophil chemotaxis dendritic cell chemotaxis MAPK cascade macrophage chemotaxis positive regulation of T cell chemotaxis regulation of neuron death positive regulation of phosphatidylinositol 3-kinase signaling negative regulation of G protein-coupled receptor signaling pathway positive regulation of T cell apoptotic process positive regulation of cell adhesion negative regulation of chemokine-mediated signaling pathway monocyte chemotaxis positive chemotaxis positive regulation of protein tyrosine kinase activity cellular response to tumor necrosis factor positive regulation of activation of Janus kinase activity regulation of signaling receptor activity G protein-coupled receptor signaling pathway cytokine-mediated signaling pathway lymphocyte chemotaxis Sumber:Amigo / QuickGO
Ortologi Spesies Manusia Tikus Entrez 6352 20304 Ensembl ENSG00000271503 ENSG00000274233 ENSMUSG00000035042 UniProt P13501 P30882 RefSeq (mRNA) NM_002985 NM_001278736 NM_013653 RefSeq (protein) NP_001265665 NP_002976 NP_038681 Location (UCSC) Chr 17: 35.87 – 35.88 Mb n/a PubMed search [2] [3]
Wikidata
Lihat/Sunting Manusia Lihat/Sunting Tikus

CCL5 (bahasa Inggris:CCL5, Regulated upon Activation, Normal T-cell Expressed, and Secreted (RANTES)) adalah kemokina peptida yang dikodikasi pada gen CCL5^[4] pada kromosom 17.^[5]

Protein CCL5 mempunyai massa 8 kDa, merupakan sitokina kemotaktik bagi sel T, eosinofil dan basofil.

Bersama dengan hormon IL-2 dan IFN-γ yang disekresi oleh sel T, CCL5 menginduksi proliferasi dan aktivasi beberapa sel NK untuk menjadi sel CHAK (bahasa Inggris:CC-Chemokine-activated killer cell).^[6]

CCL5 yang disekresi oleh sel T CD8 dikenal sebagai faktor penekan virus HIV.

Rujukan

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