Interleukin-18

Interleukin-18
Struktur yang tersedia PDB Pencarian ortolog: PDBe RCSB Daftar kode ID PDB 1J0S, 2VXT, 3F62, 4EEE, 4EKX, 4HJJ, 3WO2, 3WO3, 3WO4, 4R6U, 4XFS, 4XFT, 4XFU
Pengidentifikasi
Alias	IL18, IGIF, IL-18, IL-1g, IL1F4, interleukin 18
ID Eksternal	OMIM: 600953; MGI: 107936; HomoloGene: 1200; GeneCards: IL18; OMA:IL18 - orthologs
Pola ekspresi RNA Bgee Manusia Tikus (ortologi) Ekspresi tertinggi di skin of abdomen skin of leg rektum skin of thigh kantung empedu mucosa of transverse colon olfactory zone of nasal mucosa germinal epithelium penis manusia rongga mulut Ekspresi tertinggi di epithelium of stomach pyloric antrum mucous cell of stomach left colon skin of external ear Kerongkongan Usus dua belas jari Usus kosong limpa bibir Referensi data ekspresi selengkapnya BioGPS Data ekspresi referensi lebih lanjut
Ontologi gen Fungsi molekuler Ikatan protein plasma cytokine activity interleukin-18 receptor binding Komponen seluler sitosol extracellular region extracellular space Proses biologis positive regulation of inflammatory response cell-cell signaling cellular response to organic cyclic compound type 2 immune response MAPK cascade positive regulation of natural killer cell proliferation tidur regulation of cell adhesion positive regulation of NK T cell proliferation positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of tissue remodeling Angiogenesis T-helper 1 type immune response positive regulation of interleukin-17 production inflammatory response lipopolysaccharide-mediated signaling pathway positive regulation of activated T cell proliferation positive regulation of protein kinase B signaling positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of smooth muscle cell proliferation activation of protein kinase B activity positive regulation of transcription by RNA polymerase II positive regulation of tyrosine phosphorylation of STAT protein positive regulation of gene expression positive regulation of macrophage derived foam cell differentiation natural killer cell activation positive regulation of interferon-gamma production cholesterol homeostasis positive regulation of T-helper 2 cell differentiation negative regulation of myoblast differentiation triglyceride homeostasis cell population proliferation regulation of signaling receptor activity interleukin-6 production T-helper 1 cell cytokine production neutrophil activation natural killer cell mediated cytotoxicity cytokine-mediated signaling pathway interleukin-18-mediated signaling pathway positive regulation of NIK/NF-kappaB signaling respons imun positive regulation of NF-kappaB transcription factor activity positive regulation of T-helper 1 cell cytokine production positive regulation of cold-induced thermogenesis positive regulation of neuroinflammatory response signal transduction Sumber:Amigo / QuickGO
Ortologi Spesies Manusia Tikus Entrez 3606 16173 Ensembl ENSG00000150782 ENSMUSG00000039217 UniProt Q14116 P70380 RefSeq (mRNA) NM_001243211 NM_001562 NM_001386420 NM_008360 NM_001357221 NM_001357222 RefSeq (protein) NP_001230140 NP_001553 NP_001230140.1 NP_032386 NP_001344150 NP_001344151 Location (UCSC) n/a n/a PubMed search [1] [2]
Wikidata
Lihat/Sunting Manusia Lihat/Sunting Tikus

Interleukin-18 (bahasa Inggris:interleukin-18, interferon-gamma-inducing factor, IL-18) adalah sitokina yang merupakan ekspresi genetik IL18,^[3] dengan prekursor sepanjang 192 AA dan protein aktif sepanjang 157 AA yang meningkatkan respon peradangan tubuh dengan menginduksi sekresi interferon-gamma oleh sel T dan meningkatkan aktivitas sel NK di dalam limpa. IL-18 umumnya merupakan sekresi makrofaga dan sel Kupffer.^[4]

Peningkatan ekspresi IL-18 ditemukan pada beberapa jenis kanker, adenomiosis,^[5] dan Hashimoto tiroiditis.^[6]

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Basis data pengawasan otoritas: Nasional	Amerika Serikat

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