Trombin

Struktur yang tersedia

Pencarian ortolog: PDBe RCSB

Daftar kode ID PDB

1A2C, 1A3B, 1A3E, 1ABI, 1ABJ, 1AD8, 1AE8, 1AI8, 1AIX, 1AWF, 1AWH, 1AY6, 1B5G, 1B7X, 1BA8, 1BB0, 1BCU, 1BHX, 1BMM, 1BMN, 1BTH, 1C1U, 1C1V, 1C1W, 1C4U, 1C4V, 1C4Y, 1C5L, 1C5N, 1C5O, 1CA8, 1D3D, 1D3P, 1D3Q, 1D3T, 1D4P, 1D6W, 1D9I, 1DE7, 1DIT, 1DM4, 1DOJ, 1DWB, 1DWC, 1DWD, 1DX5, 1E0F, 1EB1, 1EOJ, 1EOL, 1FPC, 1G30, 1G32, 1G37, 1GHV, 1GHW, 1GHX, 1GHY, 1GJ4, 1GJ5, 1H8D, 1H8I, 1HAI, 1HAO, 1HAP, 1HBT, 1HLT, 1HUT, 1HXE, 1HXF, 1IHS, 1JMO, 1JOU, 1JWT, 1K21, 1K22, 1KTS, 1KTT, 1LHC, 1LHD, 1LHE, 1LHF, 1LHG, 1MH0, 1MU6, 1MU8, 1MUE, 1NM6, 1NRN, 1NRO, 1NRP, 1NRQ, 1NRR, 1NRS, 1NT1, 1NU7, 1NU9, 1NY2, 1NZQ, 1O0D, 1O2G, 1O5G, 1OOK, 1OYT, 1P8V, 1PPB, 1QBV, 1QHR, 1QJ1, 1QJ6, 1QJ7, 1QUR, 1RD3, 1RIW, 1SB1, 1SFQ, 1SG8, 1SGI, 1SHH, 1SL3, 1SR5, 1T4U, 1T4V, 1TA2, 1TA6, 1TB6, 1THP, 1THR, 1THS, 1TMB, 1TMU, 1TOM, 1TQ0, 1TQ7, 1TWX, 1UVS, 1VR1, 1VZQ, 1W7G, 1WAY, 1WBG, 1XM1, 1XMN, 1YPE, 1YPG, 1YPJ, 1YPK, 1YPL, 1YPM, 1Z71, 1Z8I, 1Z8J, 1ZGI, 1ZGV, 1ZRB, 2A0Q, 2A2X, 2A45, 2AFQ, 2ANK, 2ANM, 2B5T, 2BDY, 2BVR, 2BVS, 2BVX, 2BXT, 2BXU, 2C8Y, 2FEQ, 2FES, 2GDE, 2GP9, 2H9T, 2HGT, 2HNT, 2HPP, 2HPQ, 2HWL, 2JH0, 2JH6, 2OD3, 2PGB, 2PGQ, 2PW8, 2R2M, 2THF, 2ZFQ, 2ZFR, 2ZG0, 2ZHE, 2ZHF, 2ZHW, 2ZI2, 2ZIQ, 2ZNK, 2ZO3, 3B23, 3B9F, 3BEF, 3BEI, 3BF6, 3BIU, 3BIV, 3BV9, 3C1K, 3C27, 3D49, 3DA9, 3DD2, 3DT0, 3DUX, 3E6P, 3EE0, 3EQ0, 3F68, 3GIC, 3GIS, 3HAT, 3HKJ, 3HTC, 3JZ2, 3LDX, 3LU9, 3NXP, 3P17, 3P6Z, 3P70, 3PO1, 3QGN, 3QLP, 3QTO, 3QTV, 3QWC, 3QX5, 3R3G, 3RLW, 3RLY, 3RM0, 3RM2, 3RML, 3RMM, 3RMN, 3RMO, 3S7H, 3S7K, 3SHA, 3SHC, 3SI3, 3SI4, 3SQE, 3SQH, 3SV2, 3T5F, 3TU7, 3U69, 3U8O, 3U8R, 3U8T, 3U98, 3U9A, 3UTU, 3UWJ, 3VXE, 3VXF, 4BAH, 4BAK, 4BAM, 4BAN, 4BAO, 4BAQ, 4BOH, 4DIH, 4DII, 4DT7, 4DY7, 4E05, 4E06, 4E7R, 4H6S, 4H6T, 4HFP, 4HTC, 4THN, 5GDS, 7KME, 8KME, 1A46, 1A4W, 1A5G, 1A61, 1AFE, 1AHT, 1DWE, 1FPH, 1HAG, 1HAH, 1HDT, 1HGT, 1IHT, 1NO9, 1TBZ, 1TMT, 1UMA, 2C8W, 2C8X, 2C8Z, 2C90, 2C93, 2CF8, 2CF9, 2CN0, 2JH5, 2PKS, 2UUF, 2UUJ, 2UUK, 2V3H, 2V3O, 2ZC9, 2ZDA, 2ZDV, 2ZF0, 2ZFF, 2ZFP, 2ZGB, 2ZGX, 2ZHQ, 3DHK, 3EGK, 3JZ1, 3K65, 3PMH, 3QDZ, 4AX9, 4AYV, 4AYY, 4AZ2, 4CH2, 4CH8, 4HZH, 4I7Y, 4LOY, 4LXB, 4LZ1, 4LZ4, 4MLF, 4N3L, 4NZE, 4NZQ, 4O03, 4RKJ, 4RKO, 4RN6, 4YES, 4UD9, 4UDW, 4UE7, 4UEH, 5AF9, 5AFY, 5AFZ, 5AHG, 5CMX, 4UFD, 5EDM, 5E8E, 5EDK, 4UFE, 4UFG, 4UFF, 5A2M, 5JDU

Pengidentifikasi

Alias

F2, PT, RPRGL2, THPH1, coagulation factor II, thrombin

ID Eksternal

OMIM: 176930; MGI: 88380; HomoloGene: 426; GeneCards: F2; OMA:F2 - orthologs

Nomor EC

3.4.21.5

Pola ekspresi RNA

Bgee

Manusia

Tikus (ortologi)

Ekspresi tertinggi di

right lobe of liver
Testis
oosit
secondary oocyte
cerebellar hemisphere
right hemisphere of cerebellum
popliteal artery
Tibial arteries
fundus
embrio

Ekspresi tertinggi di

left lobe of liver
fetal liver hematopoietic progenitor cell
kantung empedu
Kantung kuning telur
janin
sexually immature organism
morula
primary oocyte
secondary oocyte
Zigot

Referensi data ekspresi selengkapnya

BioGPS


Data ekspresi referensi lebih lanjut

Ontologi gen
Fungsi molekuler	calcium ion binding signaling receptor binding peptidase activity hydrolase activity growth factor activity serine-type peptidase activity thrombospondin receptor activity Ikatan protein plasma serine-type endopeptidase activity lipopolysaccharide binding heparin binding enzyme activator activity
Komponen seluler	extracellular exosome blood microparticle endoplasmic reticulum lumen Golgi lumen membran sel extracellular region extracellular space external side of plasma membrane collagen-containing extracellular matrix
Proses biologis	blood coagulation, intrinsic pathway regulation of blood coagulation positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of collagen biosynthetic process multicellular organism development peptidyl-glutamic acid carboxylation acute-phase response positive regulation of reactive oxygen species metabolic process endoplasmic reticulum to Golgi vesicle-mediated transport positive regulation of cell growth cell surface receptor signaling pathway Regulasi gen positive regulation of release of sequestered calcium ion into cytosol positive regulation of cell population proliferation leukocyte migration negative regulation of fibrinolysis positive regulation of blood coagulation regulation of cytosolic calcium ion concentration response to wounding signal peptide processing positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway regulation of cell shape Hemostasis negative regulation of proteolysis negative regulation of platelet activation negative regulation of astrocyte differentiation positive regulation of protein phosphorylation Fibrinolisis Koagulasi Proteolisis platelet activation positive regulation of protein localization to nucleus positive regulation of lipid kinase activity regulation of complement activation antimicrobial humoral immune response mediated by antimicrobial peptide negative regulation of cytokine production involved in inflammatory response regulation of signaling receptor activity G protein-coupled receptor signaling pathway positive regulation of receptor signaling pathway via JAK-STAT blood coagulation, fibrin clot formation
Sumber:Amigo / QuickGO

Ortologi

Spesies

Manusia

Tikus

Entrez


2147


14061

Ensembl


ENSG00000180210


ENSMUSG00000027249

UniProt


P00734


P19221

RefSeq (mRNA)


NM_000506 NM_001311257


NM_010168

RefSeq (protein)


NP_000497


NP_034298

Location (UCSC)

n/a

PubMed search

^[1]

^[2]

Wikidata

Lihat/Sunting Manusia

Lihat/Sunting Tikus

Trombin (bahasa Inggris:Thrombin,^[3] Factor II, FII) adalah sejenis glikoprotein yang dibentuk oleh dan disimpan dalam hati. Sekresi protrombin ke dalam plasma darah terjadi karena stimulasi dari tromboplastin dan ion kalsium pada proses koagulasi.^[4] Dalam proses tersebut, protrombin kemudian dikonversi menjadi trombin^[5] oleh protrombinase.^[6] Lebih lanjut, trombin akan mengkonversi fibrinogen menjadi fibrin.^[6]

Vitamin K merupakan senyawa organik yang sangat penting pada sintesis protrombin.^[6]^[7]

Rujukan

↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ (Inggris) "Definition of Prothrombin". MedicineNet. Diakses tanggal 2010-04-28.
↑ (Inggris) "Prothrombin". The American Heritage® Medical Dictionary; Houghton Mifflin Company. Diakses tanggal 2010-04-28.
↑ (Inggris) "Prothrombin". Gale Encyclopedia of Medicine. Diakses tanggal 2010-04-28.
1 2 3 (Inggris) "Prothrombin". Encyclopædia Britannica. Diakses tanggal 2010-04-28.
↑ (Inggris) "Prothrombin". Mosby's Dental Dictionary. Diakses tanggal 2010-04-28.

Bacaan lanjut

(Inggris) Prothrombin 20210 Mutation. American Heart Association

Sel darah mieloid dan plasma

Hematopoiesis

Mielopoiesis
(CFU-GEMM)

CFU-GM

Granulopoiesis Mieloblas Promielosit Mielosit Metamielosit Sel pita
Monositopoiesis Monoblas Promonosit

MEP

Trombopoiesis Megakarioblas Promegakariosit
Eritropoiesis Proeritroblas Normoblas Retikulosit

Umum

Hematopoiesis ekstramedular

Jaringan mieloid

Granulosit

Monosit

Makrofag	Histiosit Sel Kupffer Makrofag alveolus Mikroglia Osteoklas Sel epiteloid Sel raksasa Sel raksasa Langhans Sel raksasa benda asing Sel raksasa Touton
Lainnya	Sel penyaji antigen Sel dendritik Sel Langerhans CFU-DL Monoblas MPS