Anastrozol

Anastrozol
Data klinis


Nama dagang	Arimidex, Aremed, Bracer, dll^[1]
Nama lain	Anastrazole; anastrozol; ICI-D1033; ZD-1033
AHFS/Drugs.com	monograph
MedlinePlus	a696018
License data	US DailyMed: Anastrozole
Kategori kehamilan	AU:C
Rute pemberian	By mouth
Kelas obat	Aromatase inhibitor; Antiestrogen
Kode ATC	L02BG03(WHO)
Status hukum
Status hukum	AU:S4 (Prescription only) UK:POM (Hanya resep) US:℞-only
Data farmakokinetika
Bioavailabilitas	Unknown (but well-absorbed in animals)^[2]
Pengikatan protein	40%^[3]^[4]
Metabolisme	Liver (~85%) (N-dealkylation, hydroxylation, glucuronidation)^[2]^[3]^[4]
Waktu paruh eliminasi	40–50 hours^[2]^[3]^[4]
Ekskresi	Urine (11%)^[2]^[3]^[4]
Pengenal
Nama IUPAC 2,2'-[5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene]bis(2-methylpropanenitrile)^[5]
Nomor CAS	120511-73-1^Y
PubChem CID	2187
IUPHAR/BPS	5137
DrugBank	DB01217^Y
ChemSpider	2102^Y
UNII	2Z07MYW1AZ
KEGG	D00960^Y
ChEBI	CHEBI:2704^Y
ChEMBL	ChEMBL1399^Y
CompTox Dashboard (EPA)	DTXSID9022607
ECHA InfoCard	100.129.723
Data sifat kimia dan fisik
Rumus	C₁₇H₁₉N₅
Massa molar	293,37 g·mol⁻¹
Model 3D (JSmol)	Gambar interaktif
SMILES N#CC(C)(C)c1cc(Cn2cncn2)cc(c1)C(C)(C)C#N
InChI InChI=1S/C17H19N5/c1-16(2,9-18)14-5-13(8-22-12-20-11-21-22)6-15(7-14)17(3,4)10-19/h5-7,11-12H,8H2,1-4H3^Y Key:YBBLVLTVTVSKRW-UHFFFAOYSA-N^Y
(verify)

Anastrozol adalah obat golongan penghambat aromatase nonsteroid generasi ketiga. Obat anastrozol digunakan untuk pengobatan kanker payudara. Obat ini memiliki mekanisme kerja dengan memblokir sintesis estrogen, sehingga pertumbuhan tumor yang sensitif estrogen menjadi terhambat.^[6]^[7]

Referensi

↑ "Anastrozole".
1 2 3 4 Lønning P (2003). "Clinical pharmacokinetics of aromatase inhibitors and inactivators". Clinical Pharmacokinetics. 42 (7): 619–631. doi:10.2165/00003088-200342070-00002. PMID 12844324. S2CID 9585901.
1 2 3 4 Lønning P, Pfister C, Martoni A, Zamagni C (Agustus 2003). "Pharmacokinetics of third-generation aromatase inhibitors". Seminars in Oncology. 30 (4 Suppl 14): 23–32. doi:10.1016/S0093-7754(03)00305-1. PMID 14513434.{{cite journal}}: Pemeliharaan CS1: Tanggal diterjemahkan otomatis (link)
1 2 3 4 Sanford M, Plosker GL (2008). "Anastrozole: a review of its use in postmenopausal women with early-stage breast cancer". Drugs. 68 (9): 1319–1340. doi:10.2165/00003495-200868090-00007. PMID 18547136. S2CID 195687223.
↑ "anastrozole". Chemical Entities of Biological Interest (ChEBI). European Molecular Biology Laboratory. Diarsipkan dari versi aslinya tanggal 2011-09-22. Diakses tanggal 2011-08-14.
↑ Anastrozole. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases. 2012. PMID 31643516.
↑ "Arimidex (anastrozole) dosing, indications, interactions, adverse effects, and more". reference.medscape.com. Diakses tanggal 2023-06-18.