SDHA

SDHA

Pengidentifikasi

Alias

SDHA, CMD1GG, FP, PGL5, SDH1, SDH2, SDHF, succinate dehydrogenase complex flavoprotein subunit A, MC2DN1, NDAXOA

ID Eksternal

OMIM: 600857; MGI: 1914195; HomoloGene: 3073; GeneCards: SDHA; OMA:SDHA - orthologs

Nomor EC

1.3.5.1

Lokasi gen (Manusia)

Kr.	Kromosom 5 (manusia)^[1]

Pita	5p15.33	Awal	218,303 pb^[1]
Pita	5p15.33	Akhir	257,082 pb^[1]

Pola ekspresi RNA

Bgee

Manusia

Tikus (ortologi)

Ekspresi tertinggi di

apex of heart
left ventricle
mucosa of transverse colon
right auricle of heart
skeletal muscle tissue
muscle of thigh
Usus dua belas jari
Otot gastrocnemius
right lobe of liver
right adrenal cortex

Ekspresi tertinggi di

right ventricle
Otot sternokleidomastoid
digastric muscle
Otot temporalis
right kidney
Otot vastus lateralis
Otot triceps brachii
Katup aorta
medial head of gastrocnemius muscle
supraoptic nucleus

Referensi data ekspresi selengkapnya

BioGPS

n/a

Ontologi gen
Fungsi molekuler	oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors succinate dehydrogenase activity Ikatan protein plasma succinate dehydrogenase (ubiquinone) activity flavin adenine dinucleotide binding electron transfer activity
Komponen seluler	mitochondrial inner membrane selubung mielin mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) membran mitokondria Nukleolus plasma membrane succinate dehydrogenase complex
Proses biologis	succinate metabolic process Siklus asam sitrat perkembangan sistem saraf Rantai transpor elektron respiratory electron transport chain mitochondrial electron transport, succinate to ubiquinone Respirasi anaerob
Sumber:Amigo / QuickGO

Ortologi

Spesies

Manusia

Tikus

Entrez


6389


66945

Ensembl


ENSG00000073578


ENSMUSG00000021577

UniProt


P31040


Q8K2B3

RefSeq (mRNA)


NM_001294332 NM_004168 NM_001330758


NM_023281

RefSeq (protein)


NP_001281261 NP_001317687 NP_004159


NP_075770

Location (UCSC)

Chr 5: 0.22 – 0.26 Mb

n/a

PubMed search

^[2]

^[3]

Wikidata

Lihat/Sunting Manusia

Lihat/Sunting Tikus

SDHA adalah berkas genetik pada kromosom 5 lokasi 5p15 di dalam inti sel, dengan ekspresi genetik berupa flavoprotein yang merupakan sub-unit A dari suksinat hidrogenase. Mutasi pada gen ini berperan dalam defisiensi rantai pernapasan di dalam mitokondria yang dikenal sebagai sindrom Leigh.^[4]

Referensi

1 2 3 GRCh38: Ensembl release 89: ENSG00000073578 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ (Inggris) "SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) [ Homo sapiens ]". Entrez Gene. Diakses tanggal 2010-11-05.

l b s Oxidoreductases: CH–CH oxidoreductases (EC 1.3)
1.3.1: NAD/NADP acceptor	Enoyl-acyl carrier protein reductase/Enoyl ACP reductase 7-Dehydrocholesterol reductase Biliverdin reductase 2,4 Dienoyl-CoA reductase Dihydroxymethyloxo-tetrahydroquinoline dehydrogenase
1.3.3: Oxygen acceptor	Dihydroorotate dehydrogenase Coproporphyrinogen III oxidase Protoporphyrinogen oxidase Bilirubin oxidase Acyl-CoA oxidase Dihydrouracil oxidase Tetrahydroberberine oxidase Secologanin synthase Tryptophan alpha,beta-oxidase Pyrroloquinoline-quinone synthase L-galactonolactone oxidase
1.3.5: Quinone	Succinate dehydrogenase SDHA SDHB SDHC SDHD
1.3.99: Other acceptors	Fumarate reductase Butyryl-CoA dehydrogenase Acyl CoA dehydrogenase ACADSB ACADS 5α-reductase SRD5A1 SRD5A2 SRD5A3 Glutaryl-CoA dehydrogenase Isovaleryl coenzyme A dehydrogenase 3-oxo-5beta-steroid 4-dehydrogenase