Melfalan

Chemical compoundTemplat:SHORTDESC:Chemical compound

Melfalan
Data klinis


Nama dagang	Alkeran, Evomela, Phelinun, others
Nama lain	(2S)-2-amino-3-{4-[bis(2-chloroethyl)amino]phenyl}propanoic acid
AHFS/Drugs.com	monograph
MedlinePlus	a682220
License data	US DailyMed: Melphalan
Rute pemberian	By mouth, intravenous, intra-arterial
Kode ATC	L01AA03(WHO)
Status hukum
Status hukum	US:℞-only^[1]^[2]^[3] EU:Rx-only^[4]
Data farmakokinetika
Bioavailabilitas	25–89% (By mouth)
Metabolisme	Hydrolysis to inactive metabolites
Waktu paruh eliminasi	1.5 ± 0.8 hours
Ekskresi	Kidney (IV: 5.8–21.3%)
Pengenal
Nama IUPAC 4-[bis(2-Chloroethyl)amino]-L-phenylalanine
Nomor CAS	148-82-3^Y
PubChem CID	460612
IUPHAR/BPS	7620
DrugBank	DB01042^Y
ChemSpider	405297^Y
UNII	Q41OR9510P
KEGG	D00369^Y
ChEBI	CHEBI:28876^Y
ChEMBL	ChEMBL852^Y
CompTox Dashboard (EPA)	DTXSID6020804
ECHA InfoCard	100.005.207
Data sifat kimia dan fisik
Rumus	C₁₃H₁₈Cl₂N₂O₂
Massa molar	305,20 g·mol⁻¹
Model 3D (JSmol)	Gambar interaktif
SMILES c1cc(ccc1C[C@@H](C(=O)O)N)N(CCCl)CCCl
InChI InChI=1S/C13H18Cl2N2O2/c14-5-7-17(8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19/h1-4,12H,5-9,16H2,(H,18,19)/t12-/m0/s1^Y Key:SGDBTWWWUNNDEQ-LBPRGKRZSA-N^Y
(verify)

Melfalan adalah obat golongan agen antineoplastik sitotoksik. Melfalan bisa digunakan dalam tata laksana mieloma multipel seperti, kanker payudara, karsinoma ovarium, polisitemia vera, adenokarsinoma ovarium lanjut, melanoma, sarkoma jaringan lunak, atau neuroblastoma.^[5]

Referensi

↑ "Alkeran- melphalan tablet, film coated". DailyMed. 18 November 2019. Diakses tanggal 23 April 2022.{{cite web}}: Pemeliharaan CS1: Tanggal diterjemahkan otomatis (link)
↑ "Evomela- melphalan injection, powder, lyophilized, for solution". DailyMed. 31 Desember 2021. Diakses tanggal 23 April 2022.{{cite web}}: Pemeliharaan CS1: Tanggal diterjemahkan otomatis (link)
↑ https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/201848s000lbl.pdf
↑ "Phelinun EPAR". European Medicines Agency (EMA). 15 September 2020. Diakses tanggal 23 April 2022.{{cite web}}: Pemeliharaan CS1: Tanggal diterjemahkan otomatis (link) Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
↑ "Melphalan". go.drugbank.com (dalam bahasa Inggris). Diakses tanggal 26 Oktober 2023.