Sel MIN-6 adalah salah satu sub-kultur sel beta, yang merupakan sel kanker jenis insulinoma,[1] yang mensekresi hormon insulin sebagai respon terhadap kenaikan konsentrasi gula darah.[2]
Seperti yang terjadi pada sel beta, hormon ACTH juga meningkatkan sekresi hormon insulin dari sel MIN-6 melalui pencerap melanokortin-2 (MCR-2) yang terdapat pada permukaan sel.[3]
Rujukan
- ↑ (Inggris) "Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets". Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo; Ishihara H, Asano T, Tsukuda K, Katagiri H, Inukai K, Anai M, Kikuchi M, Yazaki Y, Miyazaki JI, Oka Y. Diakses tanggal 2011-06-08.
- ↑ (Inggris) "Rapid Activation and Nuclear Translocation of Mitogen-activated Protein Kinases in Response to Physiological Concentration of Glucose in the MIN6 Pancreatic β Cell Line". Laboratoire Signalisation Cellulaire et Parasites, UFR Cochin Université René Descartes, Department of Nutrition and Physiological Chemistry, Osaka University Medical School; Cyril Benes, Marie Paule Roisin, Huynh Van Tan, Claudine Creuzet, Jun-ichi Miyazaki dan Remi Fagard. Diakses tanggal 2011-06-08.
- ↑ (Inggris) "ACTH stimulates insulin secretion from MIN6 cells and primary mouse and human islets of Langerhans" (pdf). Centre for Reproduction, Endocrinology and Diabetes, GKT School of Biomedical Sciences, King’s College London, Diabetes, Endocrinology and Internal Medicine, GKT School of Medicine; H T Al-Majed, P M Jones, S J Persaud, D Sugden, G C Huang, S Amiel dan B J Whitehouse. Diakses tanggal 2011-06-08.
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