Protein morfogenetik tulang 2

BMP2
Struktur yang tersedia PDB Pencarian ortolog: PDBe RCSB Daftar kode ID PDB 1ES7, 1REU, 1REW, 2GOO, 2H62, 2H64, 2QJ9, 2QJA, 2QJB, 3BK3, 3BMP, 4MID, 4N1D, 4UHY, 4UHZ, 4UI0, 4UI1, 4UI2
Pengidentifikasi
Alias	BMP2, BDA2, BMP2A, bone morphogenetic protein 2, SSFSC, SSFSC1
ID Eksternal	OMIM: 112261; MGI: 88177; HomoloGene: 926; GeneCards: BMP2; OMA:BMP2 - orthologs
Lokasi gen (Manusia) Kr. Kromosom 20 (manusia)[1] Pita 20p12.3 Awal 6,767,686 pb[1] Akhir 6,780,246 pb[1]
Pola ekspresi RNA Bgee Manusia Tikus (ortologi) Ekspresi tertinggi di cartilage tissue pancreatic ductal cell retinal pigment epithelium mucosa of sigmoid colon lower lobe of lung pylorus periodontal fiber mucosa of urinary bladder stromal cell of endometrium Glomerulus Ekspresi tertinggi di gastrula transitional epithelium of urinary bladder epithelium of stomach left colon Badan siliaris mucous cell of stomach Apical ectodermal ridge Kelenjar minyak retinal pigment epithelium pyloric antrum Referensi data ekspresi selengkapnya BioGPS Data ekspresi referensi lebih lanjut
Ontologi gen Fungsi molekuler signaling receptor binding cytokine activity co-receptor binding phosphatase activator activity growth factor activity BMP receptor binding Ikatan protein plasma NAD-retinol dehydrogenase activity SMAD binding protein heterodimerization activity transforming growth factor beta receptor binding Komponen seluler extracellular region cell surface BMP receptor complex extracellular space intracellular membrane-bounded organelle Proses biologis Sistem rangka positive regulation of Wnt signaling pathway by BMP signaling pathway positive regulation of protein phosphorylation mesenchyme development negative regulation of cell cycle odontogenesis of dentin-containing tooth telencephalon regionalization protein phosphorylation atrioventricular valve morphogenesis proteoglycan metabolic process mesenchymal cell differentiation pericardium development positive regulation of ERK1 and ERK2 cascade BMP signaling pathway involved in heart induction animal organ morphogenesis inner ear development cardiocyte differentiation negative regulation of canonical Wnt signaling pathway negative regulation of cell population proliferation positive regulation of p38MAPK cascade pathway-restricted SMAD protein phosphorylation cell fate commitment regulation of transcription, DNA-templated SMAD protein signal transduction Osifikasi in utero embryonic development mesenchymal cell proliferation involved in ureteric bud development regulation of odontogenesis of dentin-containing tooth positive regulation of transcription, DNA-templated positive regulation of Wnt signaling pathway development of the heart telencephalon development branching involved in ureteric bud morphogenesis negative regulation of Wnt signaling pathway involved in heart development cartilage development bone mineralization involved in bone maturation positive regulation of cartilage development positive regulation of neuron differentiation positive regulation of cell differentiation thyroid-stimulating hormone-secreting cell differentiation inflammatory response positive regulation of fat cell differentiation negative regulation of steroid biosynthetic process positive regulation of MAPK cascade Jalur persinyalan Notch bone mineralization Diferensiasi sel chondrocyte differentiation corticotropin hormone secreting cell differentiation positive regulation of astrocyte differentiation positive regulation of bone mineralization cellular response to organic cyclic compound positive regulation of ossification negative regulation of transcription by RNA polymerase II positive regulation of epithelial to mesenchymal transition positive regulation of phosphatase activity negative regulation of calcium-independent cell-cell adhesion positive regulation of osteoblast differentiation protein destabilization embryonic heart tube anterior/posterior pattern specification diferensiasi osteoblas Transisi epitelial-mesenkimal positive regulation of protein binding negative regulation of transcription, DNA-templated positive regulation of odontogenesis positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus negative regulation of aldosterone biosynthetic process positive regulation of osteoblast proliferation respons terhadap hipoksia positive regulation of endothelial cell proliferation positive regulation of cell migration negative regulation of cortisol biosynthetic process cell-cell signaling positive regulation of pathway-restricted SMAD protein phosphorylation cellular response to growth factor stimulus cellular response to BMP stimulus cardiac muscle tissue morphogenesis endocardial cushion morphogenesis multicellular organism development negative regulation of cardiac muscle cell differentiation positive regulation of apoptotic process negative regulation of insulin-like growth factor receptor signaling pathway positive regulation of transcription by RNA polymerase II cardiac epithelial to mesenchymal transition positive regulation of pri-miRNA transcription by RNA polymerase II positive regulation of gene expression BMP signaling pathway cardiac muscle cell differentiation cell development regulation of signaling receptor activity negative regulation of gene expression response to bacterium regulation of apoptotic process regulation of MAPK cascade Sumber:Amigo / QuickGO
Ortologi Spesies Manusia Tikus Entrez 650 12156 Ensembl ENSG00000125845 ENSMUSG00000027358 UniProt P12643 P21274 RefSeq (mRNA) NM_001200 NM_007553 RefSeq (protein) NP_001191 NP_031579 Location (UCSC) Chr 20: 6.77 – 6.78 Mb n/a PubMed search [2] [3]
Wikidata
Lihat/Sunting Manusia Lihat/Sunting Tikus

Protein morfogenetik tulang 2 atau BMP-2 termasuk ke dalam superfamili TGF-β.^[4]

Fungsi

BMP-2, seperti protein morfogenetik tulang lainnya,^[5] berperan penting dalam perkembangan tulang dan tulang rawan. Protein ini terlibat dalam lajur persinyalan hedgehog, lajur persinyalan TGF beta, dan interaksi resptor sitokin-sitokin. Protein ini juga terlibat dalam diferensiasi sel jantung dan transisi epitelial-mesenkimal.

Seperti banyak protein lainnya dari famili BMP, BMP-2 telah menunjukkan kemampuan untuk memicu diferensiasi osteoblas pada berbagai jenis sel.^[6]

BMP-2 juga barangkali terlibat dalam adipogenesis putih^[7][8] dan barangkali memiliki efek metabolis.^[7][8]

Referensi

1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000125845 – Ensembl, May 2017
2. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ↑ Sampath TK, Coughlin JE, Whetstone RM, Banach D, Corbett C, Ridge RJ, Ozkaynak E, Oppermann H, Rueger DC (Agustus 1990). "Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-beta superfamily". J. Biol. Chem. 265 (22): 13198–205. doi:10.1016/S0021-9258(19)38285-7. PMID 2376592.{{cite journal}}: Pemeliharaan CS1: Tanggal diterjemahkan otomatis (link)
5. ↑ Chen D, Zhao M, Mundy GR (Desember 2004). "Bone morphogenetic proteins". Growth Factors. 22 (4): 233–41. doi:10.1080/08977190412331279890. PMID 15621726. S2CID 22932278.{{cite journal}}: Pemeliharaan CS1: Tanggal diterjemahkan otomatis (link)
6. ↑ Marie PJ, Debiais F, Haÿ E (2002). "Regulation of human cranial osteoblast phenotype by FGF-2, FGFR-2 and BMP-2 signaling". Histol. Histopathol. 17 (3): 877–85. doi:10.14670/HH-17.877. PMID 12168799.
7. 1 2 Jin W, Takagi T, Kanesashi SN, Kurahashi T, Nomura T, Harada J, Ishii S (April 2006). "Schnurri-2 controls BMP-dependent adipogenesis via interaction with Smad proteins". Developmental Cell. 10 (4): 461–71. doi:10.1016/j.devcel.2006.02.016. PMID 16580992.{{cite journal}}: Pemeliharaan CS1: Tanggal diterjemahkan otomatis (link)
8. 1 2 Blázquez-Medela AM, Jumabay M, Boström KI (Januari 2019). "Beyond the bone: Bone morphogenetic protein signaling in adipose tissue". Obesity Reviews. 20 (5): 648–658. doi:10.1111/obr.12822. PMC 6447448. PMID 30609449.{{cite journal}}: Pemeliharaan CS1: Tanggal diterjemahkan otomatis (link)