PTEN

PTEN
Struktur yang tersedia PDB Pencarian ortolog: PDBe RCSB Daftar kode ID PDB 4O1V, 1D5R, 2KYL, 5BZX, 5BUG, 5BZZ
Pengidentifikasi
Alias	PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1, phosphatase and tensin homolog, Phosphatase and tensin homolog, PTENbeta
ID Eksternal	OMIM: 601728; MGI: 109583; HomoloGene: 265; GeneCards: PTEN; OMA:PTEN - orthologs
Nomor EC	3.1.3.48+ 3.1.3.67 3.1.3.16, 3.1.3.48, 3.1.3.67
Pola ekspresi RNA Bgee Manusia Tikus (ortologi) Ekspresi tertinggi di sperma endothelial cell Tendon Achilles skin of arm pancreatic epithelial cell middle temporal gyrus parietal pleura mucosa of ileum cardiac muscle tissue of right atrium pleura Ekspresi tertinggi di arcuate nucleus intercostal muscle median eminence olfactory tubercle Granulosit janin Rostral migratory stream Pergelangan kaki kalvaria subcutaneous adipose tissue Referensi data ekspresi selengkapnya BioGPS n/a
Ontologi gen Fungsi molekuler phosphoprotein phosphatase activity phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity phosphatidylinositol-3-phosphatase activity protein serine/threonine phosphatase activity protein tyrosine phosphatase activity protein tyrosine/serine/threonine phosphatase activity enzyme binding platelet-derived growth factor receptor binding Ikatan protein plasma protein kinase binding phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity anaphase-promoting complex binding pengikatan protein identik hydrolase activity lipid binding ubiquitin-specific protease binding ionotropic glutamate receptor binding protein tyrosine kinase binding inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity PDZ domain binding Komponen seluler sitoplasma postsynaptic membrane extracellular region mitokondria neuron projection cytoplasmic side of plasma membrane Inti sel cell projection dendritic spine myelin sheath adaxonal region Schmidt-Lanterman incisure membran plasma apikal membran sel PML body nucleoplasm sitosol postsynaptic cytosol Proses biologis multicellular organismal response to stress regulation of neuron projection development response to zinc ion positive regulation of TRAIL-activated apoptotic signaling pathway response to organic substance negative regulation of G1/S transition of mitotic cell cycle regulation of B cell apoptotic process Angiogenesis positive regulation of ERK1 and ERK2 cascade negative regulation of epithelial cell proliferation long-term depression positive regulation of excitatory postsynaptic potential cell population proliferation response to ethanol neuron projection development respons seluler terhadap hipoksia negative regulation of cell size negative regulation of cell population proliferation prepulse inhibition regulation of myeloid cell apoptotic process male mating behavior locomotory behavior dentate gyrus development positive regulation of apoptotic signaling pathway inositol phosphate metabolic process response to arsenic-containing substance Ingatan forebrain morphogenesis dendritic spine morphogenesis development of the heart central nervous system development negative regulation of axonogenesis regulation of cellular localization synapse maturation belajar atau mengingat perilaku sosial Sinaptogenesis cellular response to decreased oxygen levels prostate gland growth platelet-derived growth factor receptor signaling pathway negative regulation of dendritic spine morphogenesis brain morphogenesis negative regulation of protein phosphorylation regulation of cyclin-dependent protein serine/threonine kinase activity regulation of cellular component size response to nutrient negative regulation of synaptic vesicle clustering postsynaptic density assembly protein dephosphorylation protein stabilization positive regulation of DNA-binding transcription factor activity negative regulation of apoptotic process response to glucose perkembangan sistem saraf adult behavior phosphatidylinositol dephosphorylation positive regulation of ubiquitin-dependent protein catabolic process response to inorganic substance canonical Wnt signaling pathway phosphatidylinositol biosynthetic process negative regulation of organ growth negative regulation of ribosome biogenesis dephosphorylation locomotor rhythm central nervous system myelin maintenance regulation of axon regeneration response to estradiol response to ATP negative regulation of phagocytosis response to organic cyclic compound protein kinase B signaling cardiac muscle tissue development metabolisme lipid penuaan neuron-neuron synaptic transmission negative regulation of excitatory postsynaptic potential presynaptic membrane assembly regulation of cell cycle Maternal behavior rhythmic synaptic transmission positive regulation of cell population proliferation positive regulation of apoptotic process negative regulation of ERK1 and ERK2 cascade Migrasi sel negative regulation of myelination inositol phosphate dephosphorylation regulation of synaptic transmission, GABAergic endothelial cell migration central nervous system neuron axonogenesis long-term potentiation peptidyl-tyrosine dephosphorylation negative regulation of axon regeneration negative regulation of cardiac muscle cell proliferation positive regulation of ubiquitin protein ligase activity protein deubiquitination negative regulation of epithelial to mesenchymal transition negative regulation of keratinocyte migration cellular response to electrical stimulus negative regulation of wound healing, spreading of epidermal cells negative regulation of phosphatidylinositol 3-kinase signaling positive regulation of gene expression positive regulation of cardiac muscle cell apoptotic process response to activity cellular response to insulin stimulus cellular response to leptin stimulus positive regulation of neuron differentiation cellular response to ethanol negative regulation of potassium ion transmembrane transporter activity cellular response to nerve growth factor stimulus cellular response to insulin-like growth factor stimulus negative regulation of signaling receptor activity negative regulation of protein kinase B signaling Apoptosis negative regulation of cell migration regulation of protein stability negative regulation of focal adhesion assembly negative regulation of vascular associated smooth muscle cell proliferation transcription initiation from RNA polymerase II promoter negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of neuron projection development Sumber:Amigo / QuickGO
Ortologi Spesies Manusia Tikus Entrez 5728 19211 Ensembl ENSG00000171862 ENSG00000284792 ENSMUSG00000013663 UniProt P60484 O08586 RefSeq (mRNA) NM_000314 NM_001304717 NM_001304718 NM_008960 NM_177096 RefSeq (protein) NP_000305 NP_001291646 NP_001291647 NP_000305.3 NP_032986 Location (UCSC) n/a n/a PubMed search [1] [2]
Wikidata
Lihat/Sunting Manusia Lihat/Sunting Tikus

PTEN (bahasa Inggris:phosphatase and tensin homolog, PTEN) adalah berkas genetik pada kromosom 10 lokus 10q23.3 dengan ekspresietik berupa protein yang berfungsi sebagai enzim dengan nama PI3P. Mutasi genetik PTEN sering ditemukan pada banyak kasus kanker, sehingga gen ini sering disebut sebagai salah satu tumor suppressor.^[3]

Tidak seperti umumnya protein fosfatase tirosina, protein ekspresi PTEN lebih banyak mengkatalitik reaksi defosforilasi pada substrat fosfoinositida dan melakukan fungsinya sebagai penghambat tumor dengan menekan lintasan AKT/PKB.

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