Opioidergik

Classification of chemicals that directly modulate opioid neuropeptide systemsTemplat:SHORTDESC:Classification of chemicals that directly modulate opioid neuropeptide systems

Opioidergik adalah zat kimia yang secara langsung atau tidak langsung memodulasi fungsi reseptor opioid. Opioidergik meliputi opioid, serta modulator alosterik dan agen yang memengaruhi enzim seperti penghambat enkefalinase.

Modulator alosterik

BMS-986121: μ-PAM^[1]
BMS-986122: μ-PAM^[1]
BPRMU191: memberikan sifat agonistik pada antagonis morfinan molekul kecil^[2]
Ignavina^[3]
Oksitosin: μ-PAM^[4]
δ-PAM (lihat referensi)^[5]
Kanabidiol^[6]
Tetrahidrokanabinol^[6]
Natrium (Na⁺) ^[7]

Lihat juga

Referensi

1 2 Burford NT, Clark MJ, Wehrman TS, et al. (Juni 2013). "Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor". Proc. Natl. Acad. Sci. U.S.A. 110 (26): 10830–5. Bibcode:2013PNAS..11010830B. doi:10.1073/pnas.1300393110. PMC 3696790. PMID 23754417.{{cite journal}}: Pemeliharaan CS1: Tanggal diterjemahkan otomatis (link)
↑ Huang YH, Lin SY, Ou LC, et al. (2024). "Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia". Cell Chem Biol. 31 (11): 1885–1898.e10. doi:10.1016/j.chembiol.2024.06.013. PMID 39025070.
↑ Ohbuchi K, Miyagi C, Suzuki Y, Mizuhara Y, Mizuno K, Omiya Y, Yamamoto M, Warabi E, Sudo Y, Yokoyama A, Miyano K, Hirokawa T, Uezono Y (Agustus 2016). "Ignavine: a novel allosteric modulator of the μ opioid receptor". Sci Rep. 6 31748. Bibcode:2016NatSR...631748O. doi:10.1038/srep31748. PMC 4987652. PMID 27530869.{{cite journal}}: Pemeliharaan CS1: Tanggal diterjemahkan otomatis (link)
↑ Meguro Y, Miyano K, Hirayama S, et al. (Mei 2018). "Neuropeptide oxytocin enhances μ opioid receptor signaling as a positive allosteric modulator". J. Pharmacol. Sci. 137 (1): 67–75. doi:10.1016/j.jphs.2018.04.002. PMID 29716811.{{cite journal}}: Pemeliharaan CS1: Tanggal diterjemahkan otomatis (link)
↑ Burford NT, Livingston KE, Canals M, Ryan MR, Budenholzer LM, Han Y, Shang Y, Herbst JJ, O'Connell J, Banks M, Zhang L, Filizola M, Bassoni DL, Wehrman TS, Christopoulos A, Traynor JR, Gerritz SW, Alt A (2015). "Discovery, Synthesis, and Molecular Pharmacology of Selective Positive Allosteric Modulators of the δ-Opioid Receptor". J. Med. Chem. 58 (10): 4220–9. doi:10.1021/acs.jmedchem.5b00007. PMC 4703104. PMID 25901762.
1 2 Kathmann M, Flau K, Redmer A, Tränkle C, Schlicker E (Februari 2006). "Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors". Naunyn-Schmiedeberg's Arch. Pharmacol. 372 (5): 354–61. doi:10.1007/s00210-006-0033-x. PMID 16489449. S2CID 4877869.{{cite journal}}: Pemeliharaan CS1: Tanggal diterjemahkan otomatis (link)
↑ Shang Y, LeRouzic V, Schneider S, Bisignano P, Pasternak GW, Filizola M (2014). "Mechanistic insights into the allosteric modulation of opioid receptors by sodium ions". Biochemistry. 53 (31): 5140–9. doi:10.1021/bi5006915. PMC 4131901. PMID 25073009.