Bufotenin

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Bufotenin, juga dikenal sebagai dimethylserotonin atau 5-hydroxy-N,N-dimethyltryptamine (5-HO-DMT), adalah sebuah psikedelik serotonergik dari famili triptamin. Komponen tersebut adalah turunan dari dimetiltriptamin (DMT) psikedelik and neurotransmiter serotonin (5-hydroxytryptamine; 5-HT). Komponen tersebut adalah sebuah alkaloid yang ditemukan di beberapa spesies jamur, tumbuhan dan kodok. Komponen tersebut juga ditemukan secara alami pada tubuh manusia dalam jumlah yang kecil.^[1]^[2]^[3] Berasal dari pohon Anadenanthera colubrina dan Anadenanthera peregrina, bufotenin memiliki sejarah panjang dari pemakaian enteogenik sebagai bahan hisap di Amerika Utara.^[4]^[5]^[6]^[7]

Referensi

↑ Barker SA, McIlhenny EH, Strassman R (2012). "A critical review of reports of endogenous psychedelic N, N-dimethyltryptamines in humans: 1955-2010". Drug Testing and Analysis. 4 (7–8): 617–635. doi:10.1002/dta.422. PMID 22371425.
↑ Neumann J, Dhein S, Kirchhefer U, Hofmann B, Gergs U (2024). "Effects of hallucinogenic drugs on the human heart". Frontiers in Pharmacology. 15 1334218. doi:10.3389/fphar.2024.1334218. PMC 10869618. PMID 38370480.
↑ Kärkkäinen J, Forsström T, Tornaeus J, Wähälä K, Kiuru P, Honkanen A, Stenman UH, Turpeinen U, Hesso A (2005). "Potentially hallucinogenic 5-hydroxytryptamine receptor ligands bufotenine and dimethyltryptamine in blood and tissues". Scandinavian Journal of Clinical and Laboratory Investigation. 65 (3): 189–199. doi:10.1080/00365510510013604. PMID 16095048.
↑ Ott J (2001). "Pharmañopo-psychonautics: human intranasal, sublingual, intrarectal, pulmonary and oral pharmacology of bufotenine". Journal of Psychoactive Drugs. 33 (3): 273–281. doi:10.1080/02791072.2001.10400574. PMID 11718320. S2CID 5877023.
↑ Hamilton Morris(1 September 2021)."PODCAST 28: A talk with Jonathan Ott". The Hamilton Morris Podcast(Podcast).Patreon.Terjadi pada 49:20–50:36.https://www.patreon.com/posts/podcast-28-talk-55653035.Diakses pada 20 January 2025."[Morris:] I've used [bufotenine] a couple times, once at 50 milligrams of the freebase snorted. [...] I found it to be extremely nauseating. I found it to be qualitatively intermediate between 5-MeO-DMT and DMT in that it was more visual than my experiences with 5-MeO-DMT but less visual than my typical experiences with DMT. It had a longer duration than 5-MeO-DMT and maybe even a longer duration than DMT as well. It was about an hour. Although I don't have all that much experience snorting DMT freebase."
↑ Hamilton Morris (1 Desember 2022). "A New One-Hour Talk On 5-MeO-DMT". The Hamilton Morris Podcast. Patreon. Terjadi di 6:27–8:40, 10:15–11:13. Diakses tanggal 21 Januari 2025. [Morris:] Bufotenine is a drug that I have tried. I've tried isolated pure bufotenine and it is a psychedelic that is both pharmacologically and experientially and chemically intermediate between DMT and 5-MeO-DMT. So it has a longer duration than actually both 5-MeO-DMT and DMT. It's yet less visual than DMT but more visual than 5-MeO-DMT, so it's kind of like in-between the two. It's also very nauseating, which is the main reason that people seem not to enjoy it very much. But it is a classical psychedelic drug that produces visionary effects. And Jonathan Ott actually liked the effect of it quite a bit.{{cite web}}: Pemeliharaan CS1: Tanggal diterjemahkan otomatis (link)
↑ Tittarelli R, Mannocchi G, Pantano F, Romolo FS (Januari 2015). "Recreational use, analysis and toxicity of tryptamines". Current Neuropharmacology. 13 (1): 26–46. doi:10.2174/1570159X13666141210222409. PMC 4462041. PMID 26074742.{{cite journal}}: Pemeliharaan CS1: Tanggal diterjemahkan otomatis (link)