BMX (gen)

BMX

Struktur yang tersedia

Pencarian ortolog: PDBe RCSB

Daftar kode ID PDB
2EKX, 2YS2, 3SXR, 3SXS

Pengidentifikasi

Alias

BMX, ETK, PSCTK2, PSCTK3, BMX non-receptor tyrosine kinase

ID Eksternal

OMIM: 300101; MGI: 1101778; HomoloGene: 20411; GeneCards: BMX; OMA:BMX - orthologs

Nomor EC

2.7.10.2

Pola ekspresi RNA

Bgee

Manusia

Tikus (ortologi)

Ekspresi tertinggi di

corpus epididymis
right auricle of heart
Sumsum tulang
cardiac muscle tissue of right atrium
Testis
right coronary artery
subcutaneous adipose tissue
right lung
Tendon Achilles
Uretra

Ekspresi tertinggi di

Granulosit
atrioventricular valve
Atrium (anatomi)
lumbar spinal ganglion
tunica media of zone of aorta
Zigot
tibiofemoral joint
endocardial cushion
right lung lobe
Sumsum tulang

Referensi data ekspresi selengkapnya

BioGPS


Data ekspresi referensi lebih lanjut

Ontologi gen
Fungsi molekuler	transferase activity nucleotide binding protein kinase activity signal transducer activity metal ion binding kinase activity Ikatan protein plasma protein tyrosine kinase activity signaling receptor binding ATP binding non-membrane spanning protein tyrosine kinase activity
Komponen seluler	sitoplasma sitosol extrinsic component of cytoplasmic side of plasma membrane ruffle membrane nucleoplasm membran sel
Proses biologis	intracellular signal transduction Fosforilasi NK T cell differentiation transmembrane receptor protein tyrosine kinase signaling pathway protein phosphorylation Adhesi sel regulation of cell population proliferation peptidyl-tyrosine autophosphorylation protein autophosphorylation mesoderm development Sistem kekebalan turunan signal transduction Apoptosis phosphatidylinositol biosynthetic process adaptive immune response B cell receptor signaling pathway
Sumber:Amigo / QuickGO

Ortologi

Spesies

Manusia

Tikus

Entrez


660


12169

Ensembl


ENSG00000102010


ENSMUSG00000031377

UniProt


P51813


P97504

RefSeq (mRNA)


NM_001721 NM_203281 NM_001320866


NM_009759

RefSeq (protein)


NP_001307795 NP_001712 NP_975010


NP_033889

Location (UCSC)

n/a

PubMed search

^[1]

^[2]

Wikidata

Lihat/Sunting Manusia

Lihat/Sunting Tikus

Sitoplasma tyrosine protein kinase BMX adalah sebuah enzim yang pada manusia dikodekan oleh gen BMX.^[3]^[4]

Fungsi

Tirosin kinase bisa berupa reseptor molekul-molekul yang mengandung transmembran dan domain ekstraseluler, atau nonreceptor protein, yang tersusun secara intraselular. Satu keluarga nonreceptor TKs meliputi gen TEC, TXK, ITK, dan BTK. Semua protein ini homolognya dari Drosophila Src28 TK dan mengandung SH3 dan SH2 domain hulu dari domain TK.

Interaksi

BMX telah terbukti berinteraksi dengan:

PAK1,^[5]
PTK2,^[6]
PTPN21^[7] dan
RUFY1.^[8]

Referensi

↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tamagnone L, Lahtinen I, Mustonen T, Virtaneva K, Francis F, Muscatelli F, Alitalo R, Smith CI, Larsson C, Alitalo K (Desember 1994). "BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2". Oncogene. 9 (12): 3683–8. PMID 7970727.{{cite journal}}: Pemeliharaan CS1: Tanggal diterjemahkan otomatis (link)
↑ "Entrez Gene: BMX BMX non-receptor tyrosine kinase".
↑ Bagheri-Yarmand R, Mandal M, Taludker AH, Wang RA, Vadlamudi RK, Kung HJ, Kumar R (Agustus 2001). "Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells". J. Biol. Chem. 276 (31): 29403–9. doi:10.1074/jbc.M103129200. PMID 11382770.{{cite journal}}: Pemeliharaan CS1: DOI bebas tanpa ditandai (link) Pemeliharaan CS1: Tanggal diterjemahkan otomatis (link)
↑ Chen R, Kim O, Li M, Xiong X, Guan JL, Kung HJ, Chen H, Shimizu Y, Qiu Y (Mei 2001). "Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain". Nat. Cell Biol. 3 (5): 439–44. doi:10.1038/35074500. PMID 11331870.{{cite journal}}: Pemeliharaan CS1: Tanggal diterjemahkan otomatis (link)
↑ Jui HY, Tseng RJ, Wen X, Fang HI, Huang LM, Chen KY, Kung HJ, Ann DK, Shih HM (Desember 2000). "Protein-tyrosine phosphatase D1, a potential regulator and effector for Tec family kinases". J. Biol. Chem. 275 (52): 41124–32. doi:10.1074/jbc.M007772200. PMID 11013262.{{cite journal}}: Pemeliharaan CS1: DOI bebas tanpa ditandai (link) Pemeliharaan CS1: Tanggal diterjemahkan otomatis (link)
↑ Yang J, Kim O, Wu J, Qiu Y (Agustus 2002). "Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking". J. Biol. Chem. 277 (33): 30219–26. doi:10.1074/jbc.M111933200. PMID 11877430.{{cite journal}}: Pemeliharaan CS1: DOI bebas tanpa ditandai (link) Pemeliharaan CS1: Tanggal diterjemahkan otomatis (link)

Pranala luar

Manusia Lokasi genom BMX manusia dan halaman rincian gen BMX dalam UCSC Genome Browser.UCSC Genome BrowserLokasi genom BMX manusia dan halaman rincian gen BMX dalam UCSC Genome Browser.