Aromatase

CYP19A1

Struktur yang tersedia

Pencarian ortolog: PDBe RCSB

Daftar kode ID PDB
3EQM, 3S79, 3S7S, 4GL5, 4GL7, 4KQ8

Pengidentifikasi

Alias

CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM, cytochrome P450 family 19 subfamily A member 1

ID Eksternal

OMIM: 107910; MGI: 88587; HomoloGene: 30955; GeneCards: CYP19A1; OMA:CYP19A1 - orthologs

Nomor EC

1.14.14.14

Lokasi gen (Manusia)

Kr.	Kromosom 15 (manusia)^[1]

Pita	15q21.2	Awal	51,208,057 pb^[1]
Pita	15q21.2	Akhir	51,338,601 pb^[1]

Pola ekspresi RNA

Bgee

Manusia

Tikus (ortologi)

Ekspresi tertinggi di

plasenta
right testis
left testis
Testis
Saraf tibialis
Gonad
germinal epithelium
subcutaneous adipose tissue
right ovary
left coronary artery

Ekspresi tertinggi di

spermatocyte
secondary oocyte
Zigot
primary oocyte
cumulus cell
ovarian follicle cell
spermatid
Meninges
Testis
seminiferous tubule

Referensi data ekspresi selengkapnya

BioGPS


Data ekspresi referensi lebih lanjut

Ontologi gen
Fungsi molekuler	iron ion binding oxygen binding metal ion binding monooxygenase activity heme binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen electron transfer activity oxidoreductase activity aromatase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen steroid hydroxylase activity
Komponen seluler	endoplasmic reticulum membrane Retikulum endoplasma membran komponen integral membran
Proses biologis	estrogen biosynthetic process androgen metabolic process negative regulation of chronic inflammatory response prostate gland growth sterol metabolic process negative regulation of macrophage chemotaxis steroid biosynthetic process female gonad development female genitalia development perkembangan payudara uterus development testosterone biosynthetic process androgen catabolic process positive regulation of estradiol secretion Rantai transpor elektron
Sumber:Amigo / QuickGO

Ortologi

Spesies

Manusia

Tikus

Entrez


1588


13075

Ensembl


ENSG00000137869


ENSMUSG00000032274

UniProt


P11511


P28649

RefSeq (mRNA)

NM_000103 NM_001347248 NM_001347249 NM_001347250 NM_001347251
NM_001347252 NM_001347253 NM_001347254 NM_001347255 NM_001347256 NM_031226


NM_007810 NM_001348171 NM_001348172 NM_001348173

RefSeq (protein)

NP_000094 NP_001334177 NP_001334178 NP_001334179 NP_001334180
NP_001334181 NP_001334182 NP_001334183 NP_001334184 NP_001334185 NP_112503


NP_001335100 NP_001335101 NP_001335102 NP_031836

Location (UCSC)

Chr 15: 51.21 – 51.34 Mb

n/a

PubMed search

^[2]

^[3]

Wikidata

Lihat/Sunting Manusia

Lihat/Sunting Tikus

Aromatase, juga disebutestrogen synthetase atau estrogen synthase, adalah sebuah enzim yang bertanggung jawab untuk langkah penting dalam biosintesis dari estrogen. Enzim tersebut berkode CYP19A1, sebuah anggopta dari keluarga besar sitokrome P450 (EC 1.14.14.1), yang bersifat monooksigenase yang memicu banyak reaksi yang terjadi pada steroidogenesis. Biasanya, aromatase bertanggung jawab untuk aromatisasi androgen menjadi estrogen.

Referensi

1 2 3 GRCh38: Ensembl release 89: ENSG00000137869 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

Bacaan tambahan

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Strobel HW, Thompson CM, Antonovic L (Juni 2001). "Cytochromes P450 in brain: function and significance". Current Drug Metabolism. 2 (2): 199–214. doi:10.2174/1389200013338577. PMID 11469726.{{cite journal}}: Pemeliharaan CS1: Tanggal diterjemahkan otomatis (link)
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